REL 2026-04-22 2026-10-06 2026-10-06 Cryo-EM Structure of hERG Channel 0000-0002-5748-4670 Takeshi Murata Department of Chemistry, Graduate School of Science, Chiba University 1-33 Yayoi-cho, Inage Chiba Chiba Japan 263-8522 0000-0002-5748-4670 Takeshi Murata Department of Chemistry, Graduate School of Science, Chiba University 1-33 Yayoi-cho, Inage Chiba Chiba Japan 263-8522 Miyashita Y Moriya T Kato T Kawasaki M Yasuda S Adachi N Suzuki K Ogasawara S Saito T Senda T Murata T 8.4 10.6019/EMPIAR-13731 EMDB molecule EMD-60573 EMD-60574 EMD-60575 EMD-60576 Miyashita Y Moriya T Kato T Kawasaki M Yasuda S Adachi N Suzuki K Ogasawara S Saito T Senda T Murata T Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors Structure (London, England : 1993) Structure 11 32 1926 1935.e3 2024 English 10.1016/j.str.2024.08.021 39321803 [EMD-60573] Cryo-EM Structure of inhibitor-free hERG Channel /data/EMD-60573 micrographs - multiframe TIFF TIFF 10184 50 1 50 UNSIGNED BYTE 5760 0.83 4092 0.83
- Microscope: FEI TITAN Krios G3i - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. - Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 1.8 - 1.0 - Average electron dose per image (e-/A2): 50 - Please use 'gain.tiff' as a gain reference without rotation and y-flipping.
 [EMD-60574] Cryo-EM Structure of astemizole-bound hERG Channel /data/EMD-60574 micrographs - multiframe TIFF TIFF 11658 49 1 49 UNSIGNED BYTE 5760 0.83 4092 0.83
- Microscope: FEI TITAN Krios G3i - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. - Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 1.8 - 1.0 - Average electron dose per image (e-/A2): 50 * Please use 'gain.tiff' as a gain reference without rotation and y-flipping.
 [EMD-60575] Cryo-EM Structure of E-4031-bound hERG Channel /data/EMD-60575 micrographs - multiframe TIFF TIFF 9711 49 1 49 UNSIGNED BYTE 5760 0.83 4092 0.83
- Microscope: FEI TITAN Krios G3i - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. - Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 1.8 - 1.0 - Average electron dose per image (e-/A2): 50 * Please use 'gain.tiff' as a gain reference without rotation and y-flipping.
 [EMD-60576] Cryo-EM Structure of pimozide-bound hERG Channel /data/EMD-60576 micrographs - multiframe TIFF TIFF 7658 50 1 50 UNSIGNED BYTE 5760 0.83 4092 0.83
- Microscope: FEI TITAN Krios G3i - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. * Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 1.8 - 1.0 - Average electron dose per image (e-/A2): 50 * Please use 'gain.tiff' as a gain reference without rotation and y-flipping.