REL
2023-01-14
2023-02-06
2023-02-06
D-cycloserine and glutamate bound human GluN1a-GluN2C NMDA receptor
0000-0001-6154-6283
Tsung Han
Chou
Cold Spring Harbor Laboratory
1 Bungtown Rd
Cold Spring Harbor
New York
United States
11724
0000-0001-8296-8426
Hiro
Furukawa
Cold Spring Harbor Laboratory
1 Bungtown Rd
Cold Spring Harbor
NY
United States
11724
Chou TH
2.9
10.6019/EMPIAR-11375
EMDB
molecule
EMD-27953
EMD-27954
Chou TH
Kang H
Simorowski N
Traynelis SF
Furukawa H
Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs
Molecular Cell
Mol Cell
United States
23
82
4548
4563
2022
English
10.1016/j.molcel.2022.10.008
36309015
Structural and functional analysis of human GluN2C- and GluN2D-containing N-methyl-D-aspartate receptors. The results reveal unique inter-subunit and domain arrangements of the GluN2C containing NMDARs. These features explain the mechanism of the binding of the GluN2C specific positive allosteric modulator, PYD-106.
D-cycloserine and glutamate bound human GluN1a-GluN2C NMDA receptor
/data
micrographs - multiframe
TIFF
TIFF
15350
30
1
30
UNSIGNED BYTE
4092
0.856
5760
0.856