<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-11615" schemaVersion="0.63" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2023-07-13</depositionDate>
            <releaseDate>2023-07-28</releaseDate>
            <updateDate>2023-07-28</updateDate>
        </keyDates>
        <title>Cryo-EM Motion Corrected Micrographs of Human Prothrombin:Prothrombinase</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0003-2300-4891</authorORCID>
            <firstName>Enrico</firstName>
            <lastName>Di Cera</lastName>
            <organization type="academic">Saint Louis University</organization>
            <street>1100 S. Grand Blvd.</street>
            <townOrCity>SAINT LOUIS</townOrCity>
            <stateOrProvince>Missouri</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>63104</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0003-2300-4891</authorORCID>
            <firstName>Enrico</firstName>
            <lastName>Di Cera</lastName>
            <organization type="academic">Saint Louis University</organization>
            <street>1100 S. Grand Blvd.</street>
            <townOrCity>St. Louis</townOrCity>
            <stateOrProvince>Missouri</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>63104</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0003-2748-5530">Ruben EA</author>
            <author authorORCID="0000-0002-0566-2076">Summers B</author>
            <author authorORCID="0000-0001-5170-2000">Rau MJ</author>
            <author authorORCID="0000-0002-7907-3602">Fitzpatrick JAJ</author>
            <author authorORCID="0000-0003-2300-4891">Di Cera E</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)</fundingBody>
                <code>U24 GM129547</code>
                <country>United States</country>
            </grantReference>
            <grantReference>
                <fundingBody>National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)</fundingBody>
                <code>R01 HL139554</code>
                <country>United States</country>
            </grantReference>
            <grantReference>
                <fundingBody>National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)</fundingBody>
                <code>R01 HL147821</code>
                <country>United States</country>
            </grantReference>
            <grantReference>
                <fundingBody>National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)</fundingBody>
                <code>R01 HL049413</code>
                <country>United States</country>
            </grantReference>
            <grantReference>
                <fundingBody>National Institutes of Health/National Cancer Institute (NIH/NCI)</fundingBody>
                <code>P30 CA091842</code>
                <country>United States</country>
            </grantReference>
        </grantSupport>
        <datasetSize units="TB">3.5</datasetSize>
        <entryDOI>10.6019/EMPIAR-11615</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>molecule</scale>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-26060</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0003-2748-5530" order="1">Ruben EA</author>
                    <author authorORCID="0000-0002-0566-2076" order="2">Summers B</author>
                    <author authorORCID="0000-0001-5170-2000" order="3">Rau MJ</author>
                    <author authorORCID="0000-0002-7907-3602" order="4">Fitzpatrick JAJ</author>
                    <author authorORCID="0000-0003-2300-4891" order="5">Di Cera E</author>
                    <title>Cryo-EM structure of the prothrombin-prothrombinase complex</title>
                    <journal>Blood</journal>
                    <journalAbbreviation>Blood</journalAbbreviation>
                    <country></country>
                    <issue>24</issue>
                    <volume>139</volume>
                    <firstPage>3463</firstPage>
                    <lastPage>3473</lastPage>
                    <year>2022</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1182/blood.2022015807</externalReferences>
                    <externalReferences type="pubmed">35427420</externalReferences>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Motion Corrected Micrographs of Human prothrombin:prothrombinase</name>
        <directory>/data</directory>
        <category>micrographs - single frame</category>
        <headerFormat>MRC</headerFormat>
        <dataFormat>MRC</dataFormat>
        <numImagesOrTiltSeries>10217</numImagesOrTiltSeries>
        <framesPerImage>1</framesPerImage>
        <voxelType>32 BIT FLOAT</voxelType>
        <dimensions>
            <imageWidth>11520</imageWidth>
            <pixelWidth>0.412</pixelWidth>
            <imageHeight>8184</imageHeight>
            <pixelHeight>0.412</pixelHeight>
        </dimensions>
        <details>Gatan K3 Direct Electron Detector
GIF BioQuantum 968 energy filter
300 KV
Total Dose 50 e/A^2
Super Resolution Pixel size 0.412 Angstroms
Physical Pixel size 0.824 Angstrom 
CS 2.7 mm
-1 to -3 um defocus
Motion Corrected</details>
        <segmentationList/>
        <micrographsFilePattern>data/MotionCorrected*/*rigid_aligned.mrc</micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
