REL 2023-10-06 2023-10-23 2023-10-23 0000-0003-2239-1420 Tinghai Xu Van Andel Institute 333 Bostwick Ave NE Grand Rapids MICHIGAN United States 49503 Peter Jone Van Andel Institute 333 Bostwick Ave NE Grand Rapids MICHIGAN United States 49503 Karsten Melcher Van Andel Institute 333 Bostwick Ave NE Grand Rapids MICHIGAN United States 49503 H.Eric Xu Van Andel Institute 333 Bostwick Ave NE Grand Rapids MICHIGAN United States 49503 Xu TH Liu M Zhou XE Liang G Zhao G Xu HE Melcher K Jones PA National Institutes of Health/National Cancer Institute (NIH/NCI) R35CA209859 United States National Institutes of Health/National Cancer Institute (NIH/NCI) R50CA243878 United States 4.2 10.6019/EMPIAR-11732 EMDB molecule EMD-20281 Xu TH Liu M Zhou EX Liang G Zhao G Xu HE Melcher K Jones PA Nature United States 7827 586 151 155 2020 English 10.1038/s41586-020-2747-1 32968275

The micrographs are the average, without any realignment, of 40 raw movie frames (accumulation 65 electron per squared Angstrom in a 8 second exposure).

unaligned multiframe micrographs of human DNMT3A2-DNMT3B3 complex bound to NCP /data micrographs - multiframe TIFF TIFF 12438 40 1 40 UNSIGNED BYTE 7420 0.5359 7676 0.5359

O image file on unit 1 : image_1105/stack_0001.tif Size= 346268 K This is a TIFF file (in strips of 7676 x 2). Number of columns, rows, sections ..... 7676 7420 40 Map mode .............................. 0 (byte) Start cols, rows, sects, grid x,y,z ... 0 0 0 7676 7420 40 Pixel spacing (Angstroms).............. 0.5359 0.5359 0.5359 Cell angles ........................... 90.000 90.000 90.000 Fast, medium, slow axes ............... X Y Z Origin on x,y,z ....................... 0.000 0.000 0.000 Minimum density ....................... 0.0000 Maximum density ....................... 5.0000 Mean density .......................... 2.5000 tilt angles (original,current) ........ 0.0 0.0 0.0 0.0 0.0 0.0 Space group,# extra bytes,idtype,lens . 0 0 0 0 1 Titles : SerialEMCCD: Dose frac. image, scaled by 1.00 r/f 0