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        <keyDates>
            <depositionDate>2024-03-06</depositionDate>
            <releaseDate>2024-05-10</releaseDate>
            <updateDate>2024-05-10</updateDate>
        </keyDates>
        <title>Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0002-9330-0963</authorORCID>
            <firstName>Qing</firstName>
            <middleName>R</middleName>
            <lastName>Fan</lastName>
            <organization type="academic">Department of Molecular Pharmacology and Therapeutics, Department of Pathology and Cell Biology, Columbia University</organization>
            <street>630 West 168th Street</street>
            <townOrCity>New York</townOrCity>
            <stateOrProvince>New York</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>10032</postOrZipCode>
        </correspondingAuthor>
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            <firstName>Qing</firstName>
            <middleName>R</middleName>
            <lastName>Fan</lastName>
            <organization type="academic">Department of Molecular Pharmacology and Therapeutics, Department of Pathology and Cell Biology, Columbia University</organization>
            <street>630 West 168th Street</street>
            <townOrCity>New York</townOrCity>
            <stateOrProvince>New York</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>10032</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author>Zuo H</author>
            <author>Park J</author>
            <author>Frangaj A</author>
            <author>Ye J</author>
            <author>Lu G</author>
            <author>Manning JJ</author>
            <author>Asher WB</author>
            <author>Lu Z</author>
            <author>Hu G</author>
            <author>Wang L</author>
            <author>Mendez J</author>
            <author>Eng E</author>
            <author>Zhang Z</author>
            <author>Lin X</author>
            <author>Grasucci R</author>
            <author>Hendrickson WA</author>
            <author>Clarke OB</author>
            <author>Javitch JA</author>
            <author>Conigrave AD</author>
            <author authorORCID="0000-0002-9330-0963">Fan QR</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)</fundingBody>
                <code>R35GM141871</code>
                <country>United States</country>
            </grantReference>
        </grantSupport>
        <datasetSize units="GB">820.1</datasetSize>
        <entryDOI>10.6019/EMPIAR-11949</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>molecule</scale>
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    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-43811</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0002-8812-7385" order="1">Zuo H</author>
                    <author order="2">Park J</author>
                    <author authorORCID="0000-0002-4990-513X" order="3">Frangaj A</author>
                    <author authorORCID="0009-0004-2353-2162" order="4">Ye J</author>
                    <author order="5">Lu G</author>
                    <author authorORCID="0000-0002-6945-2254" order="6">Manning JJ</author>
                    <author authorORCID="0000-0001-7437-218X" order="7">Asher WB</author>
                    <author authorORCID="0000-0002-4262-1193" order="8">Lu Z</author>
                    <author order="9">Hu GB</author>
                    <author order="10">Wang L</author>
                    <author authorORCID="0000-0002-3317-5654" order="11">Mendez J</author>
                    <author authorORCID="0000-0002-8014-7269" order="12">Eng E</author>
                    <author order="13">Zhang Z</author>
                    <author order="14">Lin X</author>
                    <author order="15">Grassucci R</author>
                    <author authorORCID="0000-0003-1412-5747" order="16">Hendrickson WA</author>
                    <author order="17">Clarke OB</author>
                    <author authorORCID="0000-0001-7395-2967" order="18">Javitch JA</author>
                    <author authorORCID="0000-0002-7232-3891" order="19">Conigrave AD</author>
                    <author authorORCID="0000-0002-9330-0963" order="20">Fan QR</author>
                    <title>Promiscuous G-protein activation by the calcium-sensing receptor</title>
                    <journal>Nature</journal>
                    <journalAbbreviation>Nature</journalAbbreviation>
                    <country></country>
                    <year>2024</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41586-024-07331-1</externalReferences>
                    <externalReferences type="pubmed">38632411</externalReferences>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Aligned multi-frame micrographs of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>MRC</headerFormat>
        <dataFormat>MRC</dataFormat>
        <numImagesOrTiltSeries>9336</numImagesOrTiltSeries>
        <framesPerImage>60</framesPerImage>
        <voxelType>32 BIT FLOAT</voxelType>
        <dimensions>
            <imageWidth>5760</imageWidth>
            <pixelWidth>0.825</pixelWidth>
            <imageHeight>4092</imageHeight>
            <pixelHeight>0.825</pixelHeight>
        </dimensions>
        <details>The micrographs are motion corrected images of 60 raw movie frames (accumulating 74.93 electron per squared Angstrom in 3 second exposure).</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
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