REL 2024-09-05 2025-06-26 2025-06-26 Cryo-EM structures of SV2A in complex with antiepileptic drugs and botulinum neurotoxin A2 receptor-binding domain 0000-0001-9285-1256 Atsushi Yamagata RIKEN Center for Biosystems Dynamics Research 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama Kanagawa Japan 230-0045 0000-0001-9285-1256 Atsushi Yamagata RIKEN Center for Biosystems Dynamics Research 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama Kanagawa Japan 230-0045 Yamagata A Ito K Suzuki T Dohmae N Terada T Shirouzu M 6.6 10.6019/EMPIAR-12410 EMDB molecule EMD-36392 EMD-36394 EMD-36616 EMD-36397 EMD-36398 EMD-36933 EMD-36395 EMD-36396 EMD-36617 EMD-36934 EMD-36935 Yamagata A Ito K Suzuki T Dohmae N Terada T Shirouzu M Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A Nature communications Nat Commun 1 15 2024 English 10.1038/s41467-024-47322-4 38637505 SC2A-HcA2-LEV /data/imageset_1 micrographs - multiframe TIFF TIFF 6518 48 1 48 UNSIGNED BYTE 5760 0.83 4092 0.83
- 8JLC / EMD-36392 - 8JLE / EMD-36394 - 8JS8 / EMD-36616 - 8JLH / EMD-36397 - Microscope: FEI TITAN Krios - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. - Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 0.8 - 2.0 - Average electron dose per image (e-/A2): 50.8 - Please use 'gain.mrc' as a gain reference without rotation and y-flipping.
 SV2-LEV /data/imageset_2 micrographs - multiframe TIFF TIFF 10001 48 1 48 UNSIGNED BYTE 5760 0.83 4092 0.83
- 8JLI / EMD-36398 - Microscope: FEI TITAN Krios - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. - Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 0.8 - 2.0 - Average electron dose per image (e-/A2): 50.2 - Please use 'gain.mrc' as a gain reference without rotation and y-flipping.
 SV2A-HcA2 /data/imageset_3 micrographs - multiframe TIFF TIFF 5930 48 1 48 UNSIGNED BYTE 5760 0.83 4092 0.83
- 8JLF / EMD-36395 - 8JLG / EMD-36396 - 8JS9 / EMD-36617 - Microscope: FEI TITAN Krios - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. - Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 0.8 - 2.0 - Average electron dose per image (e-/A2): 50.0 - Please use 'gain.mrc' as a gain reference without rotation and y-flipping.
 SV2A-HcA2-BRV /data/imageset_4 micrographs - multiframe TIFF TIFF 6001 48 1 48 UNSIGNED BYTE 5760 0.83 4092 0.83
- 8K77 / EMD-36933, EMD-36934, EMD-36935 - Microscope: FEI TITAN Krios - Detector: Gatan K3 BIOQUANTUM - Acceleration voltage (kV): 300 - The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value. - Spherical aberration (Cs) : 2.7 - Nominal Defocus (μm): 0.8 - 2.0 - Average electron dose per image (e-/A2): 50.0 - Please use 'gain.mrc' as a gain reference without rotation and y-flipping.