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        <keyDates>
            <depositionDate>2025-12-21</depositionDate>
            <releaseDate>2026-01-19</releaseDate>
            <updateDate>2026-01-19</updateDate>
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        <title>Cryo-EM structure of human lipid phosphate phosphatase 1</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0001-9940-8003</authorORCID>
            <firstName>Hongwu</firstName>
            <lastName>Qian</lastName>
            <organization type="academic">university of science and technology of China</organization>
            <street>Huangshan Road</street>
            <townOrCity>Hefei</townOrCity>
            <stateOrProvince>Anhui Province</stateOrProvince>
            <country>China</country>
            <postOrZipCode>230000</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0001-9940-8003</authorORCID>
            <firstName>Hongwu</firstName>
            <lastName>Qian</lastName>
            <organization type="academic">University of Science and Technology of China</organization>
            <street>Huangshan Road</street>
            <townOrCity>Hefei</townOrCity>
            <stateOrProvince>Anhui Province</stateOrProvince>
            <country>China</country>
            <postOrZipCode>230000</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0009-0004-1453-8749">Yang YM</author>
            <author authorORCID="0000-0001-9940-8003">Qian QHW</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>National Natural Science Foundation of China (NSFC)</fundingBody>
                <code>32271241</code>
                <country>China</country>
            </grantReference>
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        <entryDOI>10.6019/EMPIAR-13186</entryDOI>
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        <scale>molecule</scale>
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                    <author order="1">Yang M</author>
                    <author order="2">Sun C</author>
                    <author order="3">He Y</author>
                    <author authorORCID="0000-0001-9940-8003" order="4">Qian H</author>
                    <title>Structural basis for the catalytic mechanism of human lipid phosphate phosphatases</title>
                    <journal>Nature chemical biology</journal>
                    <journalAbbreviation>Nat Chem Biol</journalAbbreviation>
                    <country>China</country>
                    <year>2026</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41589-025-02121-w</externalReferences>
                    <externalReferences type="pubmed">41513850</externalReferences>
                    <details>The micrographs are the average, without any realignment, of 40 raw movie frames (accumulating 50 electron per squared angstrom in a 1.8 second exposure).</details>
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        <name>Cryo-EM structure of human lipid phosphate phosphatase 1</name>
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        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
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        <framesPerImage>40</framesPerImage>
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        <details>Raw cryo-EM dose-fractionated movies acquired on a Titan Krios equipped with a K3 direct electron detector. Movies were recorded as multi-frame TIFF stacks with approximately 40 frames per movie at a calibrated pixel size of 0.82 Å/pixel. The data are unaligned and unprocessed, intended for motion correction and downstream single-particle analysis.</details>
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