REL
2021-07-17
2021-09-17
2021-10-19
Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the temporal cortex of an individual with limbic-predominant neuronal inclusion body 4R tauopathy
0000-0003-1579-7561
Yang
Shi
MRC-LMB
Francis Crick Avenue, Cambridge Biomedical Campus
Cambridge
Cambridgeshire
United Kingdom
CB2 0QH
Sjors
HW
Scheres
MRC-LMB
Francis Crick Avenue, Cambridge Biomedical Campus
Cambridge
Cambridgeshire
United Kingdom
CB2 0QH
Michel
Goedert
MRC-LMB
Francis Crick Avenue, Cambridge Biomedical Campus
Cambridge
Cambridgeshire
United Kingdom
CB2 0QH
Shi Y
Zhang W
Yang Y
Murzin AG
Falcon B
Kotecha A
van Beers M
Tarutani A
Kametani F
Garringer HJ
Vidal R
Hallinan GI
Lashley T
Saito Y
Murayama S
Yoshida M
Tanaka H
Kakita A
Ikeuchi T
Robinson AC
Mann DMA
Kovacs GG
Revesz T
Ghetti B
Hasegawa M
Goedert M
Scheres SHW
5.5
10.6019/EMPIAR-10767
EMDB
EMD-13223
EMD-13224
EMD-13225
Shi Y
Zhang W
Yang Y
Murzin AG
Falcon B
Kotecha A
van Beers M
Tarutani A
Kametani F
Garringer HJ
Vidal R
Hallinan GI
Lashley T
Saito Y
Murayama S
Yoshida M
Tanaka H
Kakita A
Ikeuchi T
Robinson AC
Mann DMA
Kovacs GG
Revesz T
Ghetti B
Hasegawa M
Goedert M
Scheres SHW
Structure-based classification of tauopathies
Nature
Nature
7880
598
359
363
2021
English
10.1038/s41586-021-03911-7
34588692
Shi Y
Zhang W
Yang Y
Murzin A
Falcon B
Kotecha A
van Beers M
Tarutani A
Kametani F
Garringer HJ
Vidal R
Hallinan GI
Lashley T
Saito Y
Murayama S
Yoshida M
Tanaka H
Kakita A
Ikeuchi T
Robinson AC
Mann DM
Kovacs GG
Revesz T
Ghetti B
Hasegawa M
Goedert M
Scheres SH
Structure-based Classification of Tauopathies
bioRxiv
2021
10.1101/2021.05.28.446130
Unaligned multi-frame movies
/data/GPT/Movies
micrographs - multiframe
EER
EER
10615
1351
BIT
4096
0.727
4096
0.727
Movies were acquired on a Titan Krios G4 microscope operated at 300 kV, which was equipped with a cold field-emission gun, a Falcon-IV detector, and a Selectrix X energy filter using a slit width of 10 eV. The total dose per movie is ~50 e/Å^2. Please use Movies/EER_GainReference.mrc as a gain reference without any rotation or flipping.
data/GPT/Segments_coordinates contains segment coordinates picked by crYOLO.
data/GPT/data.star contains STAR files with the metadata of the final refined segments.
data/GPT/XMLs contains EPU metadata files.
Cfeg flash time stamp:
1 | 2020-09-05 14:34:25
2 | 2020-09-05 15:19:16
3 | 2020-09-05 17:16:53
4 | 2020-09-06 00:42:08
5 | 2020-09-06 11:53:49
6 | 2020-09-06 21:50:36
Nitrogen fill time stamp:
1 | 2020-09-05 15:16:44
2 | 2020-09-05 22:38:55
3 | 2020-09-06 05:21:31
4 | 2020-09-06 12:13:43
5 | 2020-09-06 19:04:52
6 | 2020-09-07 01:48:23
data/GPT/Movies/GridSquare*/*_EER.eer
data/GPT/Segments_coordinates/*.box
data/GPT/Segments_coordinates