<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-10868" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2021-11-09</depositionDate>
            <releaseDate>2021-11-26</releaseDate>
            <updateDate>2021-11-26</updateDate>
        </keyDates>
        <title>Cryo electron microscopy of hIAPP fibrils seeded by patient-extracted fibrils</title>
        <correspondingAuthor>
            <firstName>Qin</firstName>
            <lastName>Cao</lastName>
            <organization type="academic">Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders</organization>
            <townOrCity>Shanghai</townOrCity>
            <country>China</country>
            <postOrZipCode>200240</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator>
            <firstName>Qin</firstName>
            <lastName>Cao</lastName>
            <organization type="academic">Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders</organization>
            <townOrCity>Shanghai</townOrCity>
            <country>China</country>
            <postOrZipCode>200240</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author>Cao Q</author>
            <author>Boyer DR</author>
            <author>Sawaya MR</author>
            <author>Abskharon R</author>
            <author>Saelices L</author>
            <author>Nguyen BA</author>
            <author>Lu J</author>
            <author>Murray KA</author>
            <author>Kandeel F</author>
            <author>Eisenberg DS</author>
        </authorsList>
        <datasetSize units="TB">9.9</datasetSize>
        <entryDOI>10.6019/EMPIAR-10868</entryDOI>
        <experimentType>EMDB</experimentType>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-23686</emdbEntry>
            <emdbEntry>EMD-23687</emdbEntry>
            <emdbEntry>EMD-23688</emdbEntry>
            <emdbEntry>EMD-23689</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author order="1">Cao Q</author>
                    <author authorORCID="0000-0002-4487-0230" order="2">Boyer DR</author>
                    <author authorORCID="0000-0003-0874-9043" order="3">Sawaya MR</author>
                    <author order="4">Abskharon R</author>
                    <author authorORCID="0000-0002-1904-2150" order="5">Saelices L</author>
                    <author authorORCID="0000-0001-7055-8809" order="6">Nguyen BA</author>
                    <author order="7">Lu J</author>
                    <author order="8">Murray KA</author>
                    <author order="9">Kandeel F</author>
                    <author authorORCID="0000-0003-2432-5419" order="10">Eisenberg DS</author>
                    <title>Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores</title>
                    <journal>Nature structural &amp; molecular biology</journal>
                    <journalAbbreviation>Nat Struct Mol Biol</journalAbbreviation>
                    <country></country>
                    <issue>9</issue>
                    <volume>28</volume>
                    <firstPage>724</firstPage>
                    <lastPage>730</lastPage>
                    <year>2021</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41594-021-00646-x</externalReferences>
                    <externalReferences type="pubmed">34518699</externalReferences>
                    <details>Unaligned, dose-fractionated movies. 0.533 A/pixel super-resolution. 1.5 e/A^2/frame.</details>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Unaligned K3 movies of hIAPP fibrils seeded by disease fibrils</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>MRC</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>20390</numImagesOrTiltSeries>
        <framesPerImage>30</framesPerImage>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>11520</imageWidth>
            <pixelWidth>0.533</pixelWidth>
            <imageHeight>8184</imageHeight>
            <pixelHeight>0.533</pixelHeight>
        </dimensions>
        <details>Data collected in two sessions (January and August). Each has their own gain file.</details>
        <segmentationList/>
        <micrographsFilePattern>data/*tif</micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
