<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-11812" schemaVersion="0.65" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2023-11-29</depositionDate>
            <releaseDate>2025-02-04</releaseDate>
            <updateDate>2025-02-04</updateDate>
        </keyDates>
        <title>Structure of 4R2N ClearTau</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0003-3632-6208</authorORCID>
            <firstName>Meltem</firstName>
            <lastName>Tatli</lastName>
            <organization type="academic">EPFL</organization>
            <townOrCity>Lausanne</townOrCity>
            <country>Switzerland</country>
            <postOrZipCode>1015</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0001-7682-8320</authorORCID>
            <firstName>HA</firstName>
            <lastName>Lashuel</lastName>
            <organization type="academic">EPFL</organization>
            <townOrCity>Lausanne</townOrCity>
            <country>Switzerland</country>
            <postOrZipCode>1015</postOrZipCode>
        </principalInvestigator>
        <principalInvestigator private="true">
            <authorORCID>0000-0002-1185-4592</authorORCID>
            <firstName>H</firstName>
            <lastName>Stahlberg</lastName>
            <organization type="academic">EPFL</organization>
            <townOrCity>Lausanne</townOrCity>
            <country>Switzerland</country>
            <postOrZipCode>1015</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0003-3632-6208">Tatli M</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody></fundingBody>
                <code></code>
                <country></country>
            </grantReference>
        </grantSupport>
        <datasetSize units="TB">8.4</datasetSize>
        <entryDOI>10.6019/EMPIAR-11812</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>molecule</scale>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-18874</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author order="1">Limorenko G</author>
                    <author order="2">Tatli M</author>
                    <author order="3">Kolla R</author>
                    <author order="4">Nazarov S</author>
                    <author order="5">Weil MT</author>
                    <author order="6">Schöndorf DC</author>
                    <author order="7">Geist D</author>
                    <author order="8">Reinhardt P</author>
                    <author order="9">Ehrnhoefer DE</author>
                    <author authorORCID="0000-0002-1185-4592" order="10">Stahlberg H</author>
                    <author authorORCID="0000-0003-3894-9898" order="11">Gasparini L</author>
                    <author authorORCID="0000-0001-7682-8320" order="12">Lashuel HA</author>
                    <title>Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates</title>
                    <journal>Nature communications</journal>
                    <journalAbbreviation>Nat Commun</journalAbbreviation>
                    <country></country>
                    <issue>1</issue>
                    <volume>14</volume>
                    <year>2023</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1038/s41467-023-39314-7</externalReferences>
                    <externalReferences type="pubmed">37402718</externalReferences>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Unaligned multi-frame micrographs of ClearTau 4R2N isoform</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>EER</headerFormat>
        <dataFormat>EER</dataFormat>
        <numImagesOrTiltSeries>25793</numImagesOrTiltSeries>
        <framesPerImage>1150</framesPerImage>
        <voxelType>BIT</voxelType>
        <dimensions>
            <imageWidth>4096</imageWidth>
            <pixelWidth>0.726</pixelWidth>
            <imageHeight>4096</imageHeight>
            <pixelHeight>0.726</pixelHeight>
        </dimensions>
        <details>EER-format movie files are within sub-folders under the "Images-Disc1" directory. The gain reference image is in the data folder. Raw micrographs, not motion-corrected.</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern>data/ManualPick</pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
